Talking of spiders I had a great story once mentioned in here (sadly now deleted for ever)
A man with chronic skin and scalp psoraisis flakes a lot in bed.
At the same time he is receiving treatment via radiation and PUVA lamps to control his condition. Unknown to him he is being slowly irradiated.
This make his skin radiated.
As it flakes off beside his bed, the common house spider eats the dried atomic skin and becomes the quivelent of Godzilla but in spider terms.
As you can see it is similar to the story of Godzilla, but the reverse of Spiderman, like the Hulk with a bit of The Singing Detective thrown in.
The Giant spider will be pale with psoriasis itslef and a walking, talking skin plaque intent on killing people from Abersythththyhthwwtyhthyth in Wales.
The above characters will be introduced throughout the story.
It will sell, trust me